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lapatinib major lapatinib is a cyp3a4 substrate, and concomitant use of lapatinib with strong cyp3a4 inhibitors, such as indinavir, should generally be avoided.

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dose correction is needed if this medication is co-administered with other drugs for erectile dysfunction, certain antifungal medicines such as itraconazole or ketoconazole, macrolide antibiotics such as clarithromycin or erythromycin, other antibiotics such as erythromycin, ketoconazole nizoral , itraconazole sporanox , indinavir crixivan and ritonavir norvir , medicine for high blood pressure, or hiv protease inhibitors such as indinavir crixivan and ritonavir norvir .

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